CALPROTECTIN, FECAL
Test Code: LAB9330
CPT Code: 83993
Interface Code
CALPRO
Synonym
CAALPRO
123255
CALPROTECTIN, FECES
123255
CALPROTECTIN, FECES
Specimen Type
Stool (unpreserved, random)
Specimen Container
Clean screw-capped plastic vial
Specimen Handling
Freeze (specimen is often shared with other tests).
Stool specimens should be received by the laboratory within seven days of collection. Temperature should not exceed 30°C during shipment.
Do NOT contaminate outside of container; do NOT overfill container.
Loose stools are acceptable.
Unpreserved and Random collection.
Stool specimens should be received by the laboratory within seven days of collection. Temperature should not exceed 30°C during shipment.
Do NOT contaminate outside of container; do NOT overfill container.
Loose stools are acceptable.
Unpreserved and Random collection.
Volume
1 g
Minimum Volume
0.5 g
Temperature
Frozen
Unacceptable Conditions
Serum or plasma received; stool contaminated with urine; samples taken from diapers unless portion taken has not been in contact with diaper material; preserved stool received
Methodology
Chemiluminescence
Additional Information
Limitations
• False-negative results could occur in patients who have granulocytopenia due to bone marrow depression.
• Some patients who are taking NSAIDs will have elevations in their fecal calprotectin levels.
• Results may not be clinically applicable to children younger than two years old, who have mildly increased calprotectin levels.
• Patients with IBD fluctuate between active (inflammatory) and inactive stages of the disease. These stages must be considered when using the calprotectin test.
• The use of proton pump inhibitors (PPIs), colitis, and diverticular disease may also lead to elevated calprotectin levels. Patients affected by untreated celiac disease may occasionally show elevated calprotectin values.
• Other intestinal ailments, including many gastrointestinal infections and colorectal cancer, can result in elevated levels of calprotectin. These specimens will test positive with this test. Consequently, a diagnosis of active IBD cannot be established solely on the basis of a positive result with this test.
• Fecal calprotectin is an indicator of neutrophilic presence in the stool and is not specific for IBD.
• False-negative results could occur in patients who have granulocytopenia due to bone marrow depression.
• Some patients who are taking NSAIDs will have elevations in their fecal calprotectin levels.
• Results may not be clinically applicable to children younger than two years old, who have mildly increased calprotectin levels.
• Patients with IBD fluctuate between active (inflammatory) and inactive stages of the disease. These stages must be considered when using the calprotectin test.
• The use of proton pump inhibitors (PPIs), colitis, and diverticular disease may also lead to elevated calprotectin levels. Patients affected by untreated celiac disease may occasionally show elevated calprotectin values.
• Other intestinal ailments, including many gastrointestinal infections and colorectal cancer, can result in elevated levels of calprotectin. These specimens will test positive with this test. Consequently, a diagnosis of active IBD cannot be established solely on the basis of a positive result with this test.
• Fecal calprotectin is an indicator of neutrophilic presence in the stool and is not specific for IBD.
Stability
Room temperature: 7 days (stability provided by manufacturer or literature reference)
Refrigerated: 11 days (stability provided by manufacturer or literature reference)
Frozen: 1 year (stability provided by manufacturer or literature reference)
Refrigerated: 11 days (stability provided by manufacturer or literature reference)
Frozen: 1 year (stability provided by manufacturer or literature reference)
Reference Range Information
Reference values are dependent upon methodology/instrumentation, check final report for current reference values
Turn Around Time
4-5 days
Performing Site
LabCorp
| Result Code | Result Name | Units of Measure | Result Loinc |
|---|---|---|---|
| 1230602454 | Calprotectin, Fecal | ug/g | 38445-3 |
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